Set in Europe at the time of the migration of nations (about 200-450 AD), Against Rome takes the player to that part of the continent that has not yet succumbed to the Roman Empire. Set in a small village, the player and his barbarians roam the vast forests of Germania or the barren steppes of eastern Europe to raid other settlements in their search for food, weapons and gold. These resources will help the barbarian chieftain expand his settlement and, above all, increase his reputation. While his tribe grows and flourishes, the leader obtains fame and experience and grows to be a master of warfare, until the player's barbarian empire is finally ready to take on the superpower of the time--the mighty Roman Empire and its apparently invincible army.
Every option in this game can be controlled with a mouse pointer. There are optional configurable keyboard shortcuts to access some game options but you cannot play the game with just the keyboard. The ability to drag and release a pointer button is required to select a group of soldiers/people.
The game can be played against others via the Internet or on a local area network.